Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya
Jurnal Kedokteran dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya (JKK) with registered number ISSN 2614-0411 (Online) and ISSN 2406-7431 (Print) and , is a scientific journal published by Faculty of Medicine Universitas Sriwijaya, Indonesia. JKK is a peer-reviewed, multidisciplinary, and scientific journal that publishes original research articles relevant to national health issues, including the areas of Biomedical Sciences, Clinical Medicine, and Public Health Science. JKK is an open-access journal published three times yearly (January, April, and October) to promote research in health-related fields. JKK has been nationally accredited Sinta 4 by the Ministry of Research Technology and Higher Education of the Republic of Indonesia based on SK No. 10/C/C3/DT.05.00/2025, March 21 , 2025) Jurnal Kedokteran dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya is expected to participate and contribute towards better known as a result of scientific studies and research findings that academic circles and researchers can access. JKK has been collaborating with ARIKESI (Asosiasi Riset Ilmu Kesehatan Indonesia) since 2024, intending to help increase the visibility of the results of scientific studies and research findings that academic circles and researchers can access. JKK has been published in the English language since April 2024 to broaden its reach to all countries globally and to collaborate with editors and reviewers from other countries.
Fakultas Kedokteran Universitas Sriwijaya
RESTING ECOLOGY AND SPATIAL HETEROGENEITY OF FILARIASIS MOSQUITO VECTORS IN TROPICAL WETLANDS: IMPLICATIONS FOR INTEGRATED VECTOR CONTROL IN BANYUASIN, INDONESIA
Lymphatic filariasis remains a public health challenge in tropical wetland ecosystems, where mosquito resting ecology is still poorly understood despite its importance for vector survival and control effectiveness. This study analyzed resting behavior, species composition, and spatial heterogeneity across four endemic villages in Banyuasin, Indonesia. A total of 2,752 mosquitoes representing 26 species were collected, dominated by Mansonia uniformis, Culex tritaeniorhynchus, Culex vishnui, and Mansonia annulifera, accounting for over 70% of individuals. Spatial patterns revealed that vegetation-rich wetlands favored Mansonia, while agricultural landscapes supported Culex species. Most dominant species exhibited exophilic resting behavior, whereas Culex quinquefasciatus showed more endophilic tendencies. Peak resting activity occurred between 19:00 and 22:00. Although no infective filarial larvae were detected, the high abundance of competent vectors suggests continued transmission potential. These findings highlight the importance of integrating resting ecology and landscape heterogeneity into comprehensive vector surveillance and control strategies.
Copyright (c) 2026 Rini Pratiwi, Peni Kusumasari, Fitriyanti https://creativecommons.org/licenses/by-sa/4.0
ANTIBIOTIC PROFILE IN THE TREATMENT OF CHRONIC SUPPURATIVE OTITIS MEDIA (CSOM) AT IBNU SINA HOSPITAL IN 2023-2025
Chronic suppurative otitis media (CSOM) is a chronic middle ear infection characterized by tympanic membrane perforation and persistent discharge. Proper antibiotic use is crucial to prevent resistance and complications. To determine the antibiotic profile in CSOM patients at Ibnu Sina Hospital, Makassar, from January 2023 to December 2025. This descriptive observational study used a cross-sectional design with medical record data. Samples were collected using total sampling. From 50 patients (61 prescriptions), the majority were adults (48%) with an equal gender distribution (50% male, 50% female). The most common antibiotic class was $\beta$-lactams (67%), specifically cefixime (48%). Capsules were the most dominant dosage form (44.3%), with cefixime 200 mg as the most prescribed dose (31%). The frequency of administration was mostly twice daily (96.7%), and the most frequent duration was 5 days (36.1%). Conclusion: Antibiotic use for CSOM at Ibnu Sina Hospital is dominated by $\beta$-lactams (cefixime) administered empirically. While dosage and frequency align with standards, variations in treatment duration require further evaluation.
Copyright (c) 2026 Annisa Shezan Nazafarin, Andi Sitti Fahirah Arsal, Ahmad Ardhani Pratama, Andi Tenri Sanna, Mila Habibasari https://creativecommons.org/licenses/by-sa/4.0
ASSOCIATION BETWEEN KNOWLEDGE OF HELMINTHIASIS AND DEWORMING BEHAVIOR AMONG COMMUNITY MEMBERS IN GASING, BANYUASIN REGENCY, INDONESIA
Helminth infections remain a significant public health problem, particularly in areas with limited sanitation. The success of deworming programs is strongly influenced by community behavior, which is partly determined by the level of knowledge. This study aimed to analyze the relationship between knowledge of helminth infections and deworming medication-taking behavior among residents of Gasing Village, Banyuasin. This study employed an analytic observational design with a cross-sectional approach involving 44 respondents selected through convenience sampling. Data were collected through interviews using a structured questionnaire. The results were analyzed using univariate and bivariate analyses, with the Chi-square test applied to assess the association between variables. The findings showed that 40,9% of respondents had a good level of knowledge regarding helminth infections, and 68,2% demonstrated good deworming medication-taking behavior. Bivariate analysis revealed a significant relationship between knowledge of helminth infections and deworming medication-taking behavior (p=0.001). Strengthening community health education is necessary to improve adherence to deworming medication, thereby supporting helminth infection control programs.
Copyright (c) 2026 Peni Kusumasari, Widyastuti, Rini Pratiwi https://creativecommons.org/licenses/by-sa/4.0
ASSOCIATION BETWEEN MCISAAC SCORE AND ANTIBIOTIC PRESCRIBING IN SUSPECTED BACTERIAL TONSILLITIS
Tonsillitis is a common upper respiratory tract infection in children and adolescents. Although most cases are caused by viruses, antibiotics are still frequently prescribed. The McIsaac score is used to estimate the likelihood of group A Streptococcus infection and to support rational antibiotic use, but its application in clinical practice remains variable. This study aimed to analyze the relationship between the McIsaac score and antibiotic use in tonsillitis patients. This analytic observational study with a cross-sectional design used retrospective medical record data from RSUD K.R.M.T. Wongsonegoro Semarang from January 2020 to December 2025, with a sample of 97 patients. Most patients were in the moderate McIsaac score category (83.5%). Antibiotics were prescribed in 48.5% of cases, while 45.7% fell into the moderate category. Fisher–Freeman–Halton test results showed no significant relationship between the McIsaac score and antibiotic use (p=0.314). These findings indicate that antibiotic use has not been fully based on McIsaac score assessment, highlighting the need to strengthen the implementation of antibiotic stewardship in clinical practice.
Copyright (c) 2026 Yustiana Suwanto, Aryaputri Nabila Haurani https://creativecommons.org/licenses/by-sa/4.0
FORENSIC ANALYSIS OF COMPLETE HANGING WITH A TYPICAL KNOT POSITION RESULTING IN MECHANICAL ASPHYXIA IN A SUICIDE CASE (CASE REPORT) FORENSIC ANALYSIS OF COMPLETE HANGING
This case report describes forensic findings in a young male who died due to complete hanging with a typical suspension point. External examination revealed an incomplete, upward-directed ligature mark with a parchment-like appearance, accompanied by facial petechiae. Internal examination demonstrated hemorrhagic infiltration of the neck muscles and visceral petechiae, consistent with mechanical asphyxia. The absence of defensive injuries and supporting situational evidence indicates suicidal hanging. This report highlights the importance of systematic forensic evaluation in distinguishing suicidal hanging from other manners of death. Hanging is the most frequently encountered method of suicide in forensic practice, with the primary mechanism of death being mechanical asphyxia due to compression of the neck structures. This case involves a female victim of complete hanging with a typical suspension point. External examination revealed an incomplete circular pressure abrasion, dark reddish in color, directed upward forming a “V” shape with a parchment-like texture, accompanied by facial petechiae and cyanosis of the lips and fingertips. Internal examination demonstrated hemorrhagic infiltration of the neck skin and muscles, fine froth difficult to break within the airways, and petechial hemorrhages on the heart, lungs, and liver. Based on these findings, the cause of death was determined to be mechanical asphyxia due to hanging. Careful interpretation of such findings is crucial in establishing the cause of death and differentiating suicide from other possible manners of death.
Copyright (c) 2026 Kristina Sihaloho, Widyastuti, Peni Kusumasari https://creativecommons.org/licenses/by-sa/4.0
PATERNAL EMOTIONAL SUPPORT, INFANT TEMPERAMENT, AND BREASTFEEDING DURATION AT PUSKESMAS BOGOR TIMUR IN 2026
The duration of breastfeeding determines the success of exclusive breastfeeding in mothers after giving birth. Emotional support from fathers and the temperament of babies can be factors that cause the cessation of breastfeeding. This study aims to analyze the relationship between emotional support from fathers and the temperament of babies with the duration of breastfeeding. This is a descriptive observational study with a cross-sectional design. The sampling technique used accidental sampling with a total of 55 mothers in the eight-week postpartum period. This study was conducted during December-January 2026 at the Bogor Timur Community Health Center. The research instruments were the Partner Breastfeeding Influence Scale (PBIS), Infant Characteristic Questionnaire (ICQ), and breastfeeding duration questionnaire. Univariate data analysis used frequency distribution and bivariate analysis used the chi-square test. The results showed that the father's emotional support was in the low category (54.4%), the infant's temperament was easy (50.9%), and the duration of breastfeeding was less than 1 month (54.5%). Paternal emotional support and infant temperament were significantly associated with infant breastfeeding duration (p=0.000 and p=0.001 <0.05). During the breastfeeding period, mothers need paternal emotional support and a more stable infant temperament.
Copyright (c) 2026 Rina Afrina, Tuti Rusmiati https://creativecommons.org/licenses/by-sa/4.0
THE ROLE OF VITAMIN D3 SUPPLEMENTATION ON MYASTHENIA GRAVIS COMPOSITE SCALE: A CASE REPORT
Myasthenia Gravis (MG) is a rare chronic autoimmune disorder triggered by pathogenic IgG autoantibodies and complement activation. Common clinical manifestations include ocular muscle weakness, dysphagia, dysarthria, dysphonia, limb muscle weakness, generalized skeletal muscle weakness, and respiratory muscle involvement. A 47-year-old female presented with unilateral ptosis, bilateral diplopia, dysphagia, dysphonia, dysarthria, and paresis of both upper and lower extremities. The Myasthenia Gravis Composite Scale (MGCS) score was 31. Electromyography confirmed the diagnosis of myasthenia gravis, and laboratory evaluation revealed 25-hydroxyvitamin D deficiency. During hospitalization, the patient received cholinesterase inhibitors, corticosteroids, and vitamin D3 supplementation at 5,000 IU once daily for 9 days. The MGCS score decreased to 19, indicating improved functional capacity. Conclusion: Vitamin D3 supplementation at a dose of 5,000 IU/day may provide potential clinical benefits, as reflected by a reduction in MGCS score, and may also reduce the future risk of osteoporosis secondary to 25-hydroxyvitamin D deficiency. However, the clinical improvement observed in this patient was likely also influenced by the concurrent administration of cholinesterase inhibitors and corticosteroids.
Copyright (c) 2026 Meidistya Ayu Mardhiani, Wina Sinaga, Diyah Eka Andayani https://creativecommons.org/licenses/by-sa/4.0
THE IMPACT OF OCCUPATIONAL NOISE EXPOSURE ON AUDITORY FUNCTION AND POSTURAL STABILITY: A CROSS-SECTIONAL STUDY IN AN INDUSTRIAL FACILITY IN SUMATERA
Chronic industrial noise exposure is an occupational health risk that can affect both the auditory and balance systems. This study aimed to analyze the relationship between noise intensity and duration of exposure with hearing function and postural stability among industrial workers. An analytic observational study with a cross-sectional design was conducted on 35 male workers in an industrial facility in Sumatra. Hearing function was assessed using pure-tone audiometry and DPOAE, while postural stability was evaluated through a series of clinical tests, with instability defined as at least one abnormal result. Workplace noise levels ranged from 85–99 dB, and all subjects had more than 10 years of service. The prevalence of hearing impairment was 42.9%, while postural instability reached 77.1%. Spearman correlation analysis showed no significant relationship between noise intensity or duration of exposure with hearing function and postural stability (p > 0.05), and no association was found between hearing impairment and postural instability (p = 0.147). The high prevalence of both conditions without significant linear correlation may be influenced by the homogeneous range of noise exposure and duration among the study subjects.
Copyright (c) 2026 Yulia Anggraini, Abla Ghanie, Ahmad Hifni https://creativecommons.org/licenses/by-sa/4.0
THE RELATIONSHIP BETWEEN LENGTH OF SENTENCE AND LEVELS OF ANXIETY AND DEPRESSION AMONG INMATES AT THE RUTAN KELAS IIB TRENGGALEK
Mental health disorders, particularly anxiety and depression, are common concerns among inmates during incarceration. This study aimed to examine the association between sentence length and levels of anxiety and depression among inmates at Rutan Kelas IIB Trenggalek. This quantitative study employed an analytic correlational design with a cross-sectional approach. The population included all inmates at Rutan Kelas IIB Trenggalek, with a total sample of 73 respondents selected through purposive sampling based on predefined inclusion criteria. Anxiety and depression were assessed using the Patient Health Questionnaire-4 (PHQ-4), while sentence length data were obtained from institutional administrative records. Data were analyzed using Spearman’s rank correlation test with a significance level of p < 0.05. The results showed that the majority of inmates screened negative for anxiety and depression symptoms. No significant association was found between sentence length and levels of anxiety or depression. These findings suggest that sentence length is not significantly related to anxiety or depression among inmates. Nevertheless, routine and continuous mental health screening remains necessary for early detection of psychological symptoms in the detention center setting.
Copyright (c) 2026 Yohana Christy, Syeikhu Alfa Ridho https://creativecommons.org/licenses/by-sa/4.0
A CROSS-SECTIONAL STUDY OF NUTRITIONAL STATUS AND ATOPIC DERMATITIS IN ADOLESCENTS
Atopic dermatitis is the number one disease among the top 10 skin diseases affecting children. Abnormal nutritional status can affect the immune system and increase the risk of infection and allergic diseases, including atopic dermatitis. This study aimed to determine the association between nutritional status and the occurrence of atopic dermatitis in adolescents. An analytic observational study with a cross-sectional design was conducted involving 204 adolescents aged 10–18 years selected through simple random sampling from medical records at Cengkareng Regional General Hospital. Nutritional status was assessed using body mass index-for-age, while the diagnosis of atopic dermatitis was obtained from physicians’ medical records. Data analysis was performed using the Chi-Square test with SPSS. The results showed the study subjects had normal nutritional status (50.5%) and atopic dermatitis (38.7%). Atopic dermatitis was more common in the overweight and obese nutritional status groups (54.2% and 54.8%). There was a significant relationship between nutritional status and the incidence of atopic dermatitis (p=0.000). Nutritional status was significantly associated with the incidence of atopic dermatitis in adolescents.
Copyright (c) 2026 Ida Effendi, Puti Maharani Diwa https://creativecommons.org/licenses/by-sa/4.0
COMPARISON OF TCM RESULTS BASED ON NUTRITIONAL STATUS IN PEDIATRIC PULMONARY TB PATIENTS AT BBKPM DURING THE 2023–2024 PERIOD
Hipertensi adalah masalah kesehatan global dengan prevalensi tinggi dan risiko komplikasi serius, terutama pada lansia (34,1% di Indonesia). Penelitian cross-sectional pada 382 lansia hipertensi di Puskesmas Grogol menganalisis hubungan pengetahuan dengan self-management. Instrumen penelitian valid dan reliabel (Alpha Cronbach 0,807 untuk pengetahuan; 0,817 untuk self-management). Hasil menunjukkan pengetahuan baik 16,2%, cukup 51,0%, kurang 32,7%; sedangkan self-management baik 4,7%, cukup 77,2%, buruk 18,1%. Uji Chi-Square menemukan hubungan signifikan (χ² = 40,251; p = 0,001) dengan kekuatan lemah–sedang (Cramer's V = 0,229). Temuan menegaskan perlunya edukasi kesehatan berkelanjutan dan dukungan keluarga maupun tenaga kesehatan agar pengelolaan hipertensi pada lansia lebih optimal dan kualitas hidup meningkat.
Copyright (c) 2026 Wulan Purnamasyani, Yusriani Mangerangi, Sidrah darma, Edward Pandu Wiriansya, Andi Husni Esa Purnamasyani s https://creativecommons.org/licenses/by-sa/4.0
THE RELATIONSHIP BETWEEN CYBERBULLYING AND STRES LEVELS IN UNIVERSITY STUDENTS
The Relationship between Cyberbullying and Stres Level on Students. Children are at that stage of development when they can be pressured. If that pressure becomes more than they can bear, it can lead to stres. There's no alternative for students to social media as a means of self-development. Excessive use of social media can also result in cyberbulling. The purpose of this study was to find out the relationship between cyber bullying with stres on health student students in Faculty of Health Science University Muhammadiyah Surakarta. Design and methods: This research utilised a quantitative correlational cross-sectional design. A total of 129 respondents were sampled using purposive sampling. Data were collected through questionnaires consisting of the Cyberbullying and Online Aggression Survey with a validity of (0.436-0.928) and the Perceived Stres Scale (PSS-10) questionnaire with a Cronbach's alpha of (0.81). The data were analysed using Spearman's Rho test. The findings indicate an association between cyberbullying victimisation and the school-related stres of students (p-value = 0.001) as well as a relationship between cyberbullying behavior and school-related student stres (p-value = 0.003). This line of research should generate insight into the effects of cyberbullying on stres.
Copyright (c) 2026 Adelia Dwi Mareta, Wita Oktaviana Wita https://creativecommons.org/licenses/by-sa/4.0
FACTORS ASSOCIATED WITH NEONATAL OUTCOMES IN PREMATURE RUPTURE OF MEMBRANES
Premature rupture of membranes (PROM) increases the risk of maternal infection and neonatal morbidity. A cross-sectional study at Pertamedika Ummi Rosnati Hospital (July–October 2025) involved 31 pregnant women with PROM. Data included maternal age, leukocyte count, birth weight, gestational age, and infant outcomes (NICU vs. rooming-in). The mean maternal age was 29.5 years, birth weight 2682 g, and leukocyte count 13.3 thousand/μL. Infant birth weight differed significantly between the NICU (2300 g) and rooming-in (2839 g) groups (p=0.001). Preterm gestational age was associated with NICU admission (p=0.003), with 66.7% of preterm infants requiring NICU admission. Birth weight was strongly correlated with Apgar score (r=0.599; p<0.001), while maternal age and leukocyte count were not significant. Analysis indicates that birth weight and gestational age are the main factors in neonatal outcomes in PROM. Close monitoring and clinical management are needed to improve outcomes.
Copyright (c) 2026 Putri Irmayani, Cut Meurah Yeni, Rena Meutia https://creativecommons.org/licenses/by-sa/4.0
NEUROLYTIC SPLANCHNIC NERVE BLOCK WITH ALCOHOL FOR UPPER ABDOMINAL CANCER PATIENTS: A SYSTEMATIC REVIEW
Pain is the most common symptom experienced by approximately 66% of patients with advanced, metastatic, or terminal cancer. Splanchnic nerve block with neurolytics can help reduce pain and is indicated for treating pain caused by malignant tumors in the retroperitoneum and upper abdomen. This systematic review used data from electronic databases (PubMed, ScienceDirect, ProQuest, and EPMC) to identify studies published in English between 2015 and 2025; five studies were included for review. Neurolytics with alcohol concentrations between 50% and 99.7% and injection volumes from 5 mL to >20 mL consistently provided significant pain reduction in patients with intra-abdominal pain due to cancer in the first three months. The potential for reducing opioid use and various techniques make splanchnic nerve neurolytics one of the therapeutic options in palliative pain management.
Copyright (c) 2026 Aidyl Fitrisyah, Nico Adithia Prawira, Devadiza Friankasari https://creativecommons.org/licenses/by-sa/4.0
BACK PAIN IN PARKINSONISM: EXPLORING PAIN GENERATORS AND INTERVENTIONAL MANAGEMENT: A CASE SERIES
Pain is a common non-motor symptom in parkinsonism, often overlooked despite its significant clinical impact. The most common form is Parkinson's disease (PD), followed by secondary and atypical parkinsonisms such as PSP. Two cases presented with musculoskeletal-spinal pain as the chief complaint: a PD patient with upper back pain that improved after an erector spinae nerve block, and a PSP patient with lumbar facet pain that improved after an intra-articular steroid injection. Pain in parkinsonism can originate from muscles, bones, joints, discs, ligaments, fascia, or nerves, requiring careful evaluation. Both cases demonstrate the effectiveness of pain injection interventions in patients unresponsive to conservative therapy. Appropriate pain assessment and management are crucial to improving the quality of life of parkinsonism patients.
Copyright (c) 2026 Ismi Hamdani, Lie Anto, Irma Savitri, Tiara Aninditha, Nurul Fadli, Yusak Mangara Tua Siahaan, Dyah Tunjungsari, Henry Riyanto Sofyan https://creativecommons.org/licenses/by-sa/4.0
ERECTOR SPINAE PLANE BLOCK AS A RESCUE THERAPY IN CHRONIC POSTHERPETIC NEURALGIA: A CASE REPORT
Postherpetic Neuralgia (PHN) is a persistent neuropathic pain following Herpes Zoster, particularly in the elderly. A case is reported of a 70-year-old man with PHN two months after HZ, experiencing burning and throbbing pain in the right T11–12 thoracic dermatomes with a pain scale of 8/10, paroxysmal in nature up to 10 times/day, triggered by touch, and disturbing sleep. The pain was unresponsive to gabapentin 1,800 mg/day and amitriptyline 12.5 mg/day. Two perineural injections of 5% dextrose reduced the pain to 6/10. At week 13, an ultrasound-guided erector spinae plane block was performed at the T12 level using 2% lidocaine (10 mL) and dexamethasone 5 mg, which rapidly reduced the pain from 6/10 to 0/10, with sustained improvement and discontinuation of medication. No complications were found. This case shows the erector spinae plane block as a safe, minimally invasive, and effective rescue therapy for refractory PHN.
Copyright (c) 2026 Lie Anto, Ismi A. Hamdani, Irma Savitri, Tiara Aninditha, Nurul Fadli, Yusak Mangara Tua Siahaan, Dyah Tunjungsari, Henry Riyanto Sofyan https://creativecommons.org/licenses/by-sa/4.0
A POSSIBLE MODALITY OF INTERVENTION IN A SURGICALLY IMPOSSIBLE CASE OF GIANT CORONARY ANEURYSM: A SUCCESSFUL CASE
Giant coronary artery aneurysms (CAAs), defined as dilations exceeding 20 mm or four times the normal artery diameter, are rare clinical entities with limited management guidelines. Most cases are discovered incidentally, but complications can be life-threatening. Treatment remains controversial, with options including medical therapy, percutaneous intervention, and surgery. We report the case of a 64-year-old male with chest pain and high-risk NSTEMI, found to have a de novo giant saccular aneurysm in the mid-left anterior descending artery (LAD) through coronary CT angiography. Coronary angiography confirmed significant LAD and LCX stenosis alongside aneurysmal progression. Surgery was ruled out due to high intraoperative risk. After multidisciplinary deliberation, percutaneous coronary intervention (PCI) using overlapping covered stents was performed, successfully excluding the aneurysm. The patient’s condition stabilized post-procedure, and he was discharged in good condition with continued outpatient follow-up. This case demonstrates that percutaneous intervention with covered stents can be a safe and effective treatment for giant CAAs in select high-risk patients when surgical options are limited. It highlights the role of advanced imaging, intravascular ultrasound, and multidisciplinary decision-making in guiding individualized treatment. Further research is essential to establish optimal management strategies and long-term outcomes for patients with giant CAAs.
Copyright (c) 2026 Sidhi Laksono, Axel Jusuf, Hillary Kusharsamita https://creativecommons.org/licenses/by-sa/4.0
PROFILE OF KNEE OSTEOARTHRITIS PATIENTS IN THE DEPARTMENT OF PHYSICAL MEDICINE AND REHABILITATION, MOHAMMAD HOESIN HOSPITAL, PALEMBANG
Osteoarthritis (OA) is a common disease . degenerative musculoskeletal disease , especially between That elderly . Osteoarthritis of the knee is That most common form And is marked by pain , stiffness , and limited range from movement , leading to decrease physique function And quality from This life​ descriptive cross-sectional study aims to describe That characteristics from knee OA patients at Mohammad Hoesin Regional Hospital , Palembang, including sociodemographic factors , BMI, clinical manifestation , duration diagnosis , comorbidities , treatment , and Compliance . Data obtained . from Be patient interview And medical notes And analyzed using SPSS version 26. Most of the Patients were mostly female (88.5%), had normal BMI (61.5%), and mild symptoms. pain (69.2%), bilateral involvement (73.1%), mild OA value (76.9%), and currently functional ability (46.2%) . The majority have diagnosed For Again compared to One years (92.3%), with NO history trauma (61.5%) or comorbidities (69.2%). TENS and the exercise is most often managed therapy , with Again compared to two treatment modality provided (100.0%) and use of NSAIDs reported in 30.4% of patients . Most of them not using ongoing assistance (96.4%) and did not undergo TKR (96.4%). Treatment obedience is very good , with all patient attend therapy 2–3 times per week . In conclusion , knee OA patients on this hospital is mostly Woman with mild bilateral disease And Good treatment compliance .
Copyright (c) 2026 Rara Intan Rahmawati, Jalalin, Indri Seta Septadina, Margareta Dewi Dwiwulandari, Nyimas Fatimah https://creativecommons.org/licenses/by-sa/4.0
QUALITY OF LIFE OF CENTRAL NERVOUS SYSTEM TUMOR PATIENTSWITH CANCER PAIN
Cancer pain is the main symptom experienced by patients with central nervous system (CNS) tumors and significantly affects quality of life. A cross-sectional study at Dr. Mohammad Hoesin General Hospital, Palembang (March–June 2025) involved 89 patients using consecutive sampling. Data were obtained from medical records and structured interviews. Quality of life was assessed using the EORTC QLQ-30, while pain intensity was assessed using the NPRS. The majority of patients were female (56.2%), aged <60 years (75.3%), with secondary (55.1%) and intracranial (76.4%) tumors. Most experienced mild pain (56.2%) and received non-opioid therapy (70.8%). Results showed a moderate quality of life, with relatively high cognitive function, but pain intensity was negatively correlated with quality of life (r = -0.321; p = 0.002). Severe pain increased the risk of poor quality of life 4.7-fold, while tumor type increased the risk 5.1-fold. These findings confirm that effective pain management, appropriate analgesic selection, and definitive therapy play an important role in improving the quality of life of CNS tumor patients.
Copyright (c) 2026 Karina, Henry Sugiharto, Yunni Diansari, Erial Bahar https://creativecommons.org/licenses/by-sa/4.0
MODIFIED LOW-DOSE FORMALIN PRESERVATION: IN THE ANATOMICAL-SURGICAL DISSECTION & PROSECTED ANATOMICAL MODELS: A CASE REPORT
The development of cadaver preservation has been fast-paced. The subtraction of formalin dose in embalming has been used since many negative factors were found in long-term usage. Preventing putrefaction progress on the cadavers, ensuring no risk of infection when in contact with a dead body, preventing hardening and retention of color tissue and organs, preventing desiccation, inhibit fungal or bacterial growth are the main goals of embalming for anatomical purposes. The new formula has been developed by using low-dose formalin, ethanol, phenol, and sodium chloride (Modified Low-Dose Formalin). This method can be used in practical anatomical-surgical dissection using either cadavers or anatomical models with low-cost maintenance.
Copyright (c) 2025 Fifi Veronica, Resti Gradia, Lulu L. Fitri https://creativecommons.org/licenses/by-sa/4.0
HYPERTENSION KNOWLEDGE AND SELF-MANAGEMENT AMONG OLDER ADULTS AT GROGOL COMMUNITY HEALTH CENTER
Hypertension is a global health problem with high prevalence and serious complication risks. The elderly are a vulnerable group, with a prevalence of hypertension reaching 34.1% in the Indonesian elderly population. This study aims to analyze the relationship between knowledge levels and self-management in elderly people with hypertension in the Grogol Community Health Center area. The study used a cross-sectional design with a sample of 382 elderly people with hypertension aged ≥ 60 years selected through cluster random sampling. The research instruments had been tested for validity (Pearson Product Moment) and reliability (Cronbach's Alpha 0.807 for knowledge; 0.817 for self-management). The results showed the distribution of knowledge levels: good 16.2%, adequate 51.0%, poor 32.7%; and self-management: good 4.7%, adequate 77.2%, poor 18.1%. The Chi-Square test showed a significant relationship between knowledge and self-management (χ² = 40.251; p = 0.001) with a weak to moderate strength of relationship (Cramer's V = 0.229). These findings indicate that health education needs to be strengthened so that hypertension management can be more optimal.
Copyright (c) 2026 Atika Laila Salsabilla, Agus Sudaryanto https://creativecommons.org/licenses/by-sa/4.0
THE RELATIONSHIP BETWEEN MENTAL HEALTH AND FUNCTIONAL CONSTIPATION AMONG ADOLESCENTS
Constipation is a common digestive problem that is divided into primary (functional) and secondary. Functional constipation is diagnosed using the Rome IV criteria, which include symptoms such as straining, hard stools, incomplete defecation, and a sensation of anorectal obstruction. Adolescents, as a transitional phase of puberty, are vulnerable to mental health problems that can affect digestion. This study aimed to analyze the relationship between mental health and functional constipation in 308 grade 10 students of SMA Negeri 1 Surakarta (October 10, 2024) using a cross-sectional design. The independent variable was mental health (the Rome IV red flag question), while the dependent variable was functional constipation (Rome IV and BSFS). Chi-square analysis showed a significant association between depression and functional constipation (p=0.006; OR 4.09; 95% CI 1.403–11.913). Psychological conditions have been shown to trigger constipation, so early detection, prevention, and counseling with parents, teachers, and health professionals are important to improve the quality of life of adolescents.
Copyright (c) 2026 Evi Rokhayati, Adila Putri Istiqomah, Tri Oktaviyantini, Fadhilah Tia Nur https://creativecommons.org/licenses/by-sa/4.0
RELATIONSHIP BETWEEN OCCUPATION AND REACTIVE HBSAG TTI SCREENING IN DONORS AT THE INDONESIAN RED CROSS IN MAKASSAR CITY IN 2022-2023
Hepatitis B is a major global health problem that is deadly, with the risk of transmission being through blood. Therefore, blood safety efforts are carried out by screening for Transfusion-Transmitted Infections (TTI). This study aims to analyze the relationship between occupational type and reactive TTI screening results for HBsAg in donors at the Indonesian Red Cross Blood Transfusion Unit in Makassar City in 2022–2023. This study used a cross-sectional analytical descriptive design utilizing secondary data from 665 voluntary donors whose TTI screening results were reactive to HBsAg at the Indonesian Red Cross Blood Transfusion Unit in Makassar City in the period 2022–2023. Data analysis to examine the relationship between occupational variables and reactive TTI results was performed using the Chi-Square Test. The results showed a significant relationship between occupation and reactive TTI results of HBsAg donors with a p-value of 0.018 (p < 0.05). These findings suggest that occupational type may act as a risk factor for possible exposure to or infection with the hepatitis B virus.
Copyright (c) 2026 Muhammad Ikhlasul Amal, Sri Julyani, Andi Millaty Halifah Dirgahayu Lantara, Irmayanti, Abdul Mubdi Ardiansar Arifuddin Karim https://creativecommons.org/licenses/by-sa/4.0
CORRELATION OF APOLIPOPROTEIN B LEVELS WITH THE DEGREE OF CORONARY ARTERY STENOSIS IN CHRONIC CORONARY SYNDROME PATIENTS
Apolipoproteins are structural components of plasma lipoproteins that involved in lipoprotein metabolism and lipid transport, reflect the number of circulating atherogenic particles. This study aims to investigate the correlation between serum apolipoprotein B levels and the degree of coronary artery stenosis in patients with chronic coronary syndrome. A cross-sectional study design was used, involving 34 patients selected from a total population of 69 individuals. Data were collected from July 2024 to September 2024. The results showed that most respondents had elevated apolipoprotein B levels, with a mean value of 141.41 ± 25.06 mg/dL, and SYNTAX score of ≥ 23, with a mean value of 24.09 ± 2.69. Pearson’s correlation test indicated a significant relationship between apolipoprotein B levels and SYNTAX scores (p = 0.029, r = 0.376). Multivariate analysis revealed a significant p-value for apolipoprotein B (p = 0.017) with a positive regression coefficient.
Copyright (c) 2026 Muhammad Novran Chalik, Erwin Sukandi, Irfannuddin, Syamsu Indra, Zen Ahmad https://creativecommons.org/licenses/by-sa/4.0
MOLECULAR DOCKING ANALYSIS OF THE BIOACTIVE COMPOUND EMODIN WITH VEGFR2 IN CERVICAL CANCER
Cervical cancer remains a leading cause of cancer-related mortality among women and represents the third most common cancer globally. Elevated VEGF expression in cervical cancer is associated with poor prognosis, highlighting the relevance of anti-VEGF therapeutic strategies. Several studies have shown that emodin, a natural anthraquinone derivative mainly isolated from Rheum palmatum, inhibits VEGF-stimulated proliferation, migration, and formation of endothelial cells. This study aims to characterize the interaction between emodin and the VEGF receptor in cervical cancer through in silico molecular docking. The workflow included preparation of the compound structure, preparation of the target protein structure, docking protocol validation, and docking of the compound to the receptor. Lower binding energy reflects a stronger and more stable interaction. The docking analysis showed that the emodin–VEGFR2 complex exhibits a binding energy of −7.78 kcal/mol, forming three hydrogen bonds with GLU915, CYS917, and LEU838, as well as three van der Waals interactions with PHE916, GLY920, and VAL846. These findings demonstrate a stable interaction between emodin and VEGFR2 and suggest its potential as a lead compound for further development of VEGFR2-targeted inhibitors, underscoring the need for subsequent in vitro and in vivo validation.
Copyright (c) 2026 Innayah Rania Farzana, Rara Inggarsih, Ziske Maritska, Ayeshah Augusta Rosdah, Soilia Fertilita https://creativecommons.org/licenses/by-sa/4.0
LEVEL OF KNOWLEDGE OF ELEMENTARY SCHOOL CHILDREN ABOUT THE DANGERS OF SMOKING AT SD NEGERI 9 RAPE RAPE
Smoking is a habit that has a negative impact on health, but now many children are starting to smoke from an early age. Elementary school children aged 6–12 years are in the process of forming basic knowledge, including an understanding of the dangers of smoking. This study aims to assess the level of knowledge of students at SD NEGERI 9 RAPE-RAPE about the dangers of smoking. This descriptive study with a cross-sectional design involved 83 respondents selected using total sampling and a questionnaire that had been tested for validity and reliability. Data analysis was performed descriptively using frequency distribution and ANOVA tests. The results showed low knowledge about smoking (84.3%) and the dangers of smoking (57.8%), with significant differences between classes (p<0.05). These findings indicate the need to improve health education and integrate material on the dangers of smoking into elementary school learning.
Copyright (c) 2026 Audry Azila Jasmine, Shulhana Mokhtar, Sidrah Darma, Dwi Anggita, Santriani Hadi https://creativecommons.org/licenses/by-sa/4.0
THE EFFECT OF ACNE VULGARIS ON BODY IMAGE, SELF-ESTEEM, AND SELF-CONFIDENCE AMONG ADOLESCENTS
Acne vulgaris, or acne, is a common skin problem among adolescents, primarily due to hormonal, physical, psychological, and social changes. This study aims to analyze the impact of acne on body image, self-esteem, and self-confidence among adolescents in Islamic boarding schools. A quantitative method with a case-control design was used on 170 respondents (90 cases, 80 controls). The research instruments included the BAS-2 for body image, the GSES for self-confidence, and the RSES for self-esteem. Analysis was conducted using the chi-square test (95% CI) and path analysis. The results showed that acne directly affected body image (b=0.64; p=0.042), self-esteem (b=-1.16; p=0.001), and self-confidence (b=-0.70; p=0.045). Indirectly, body image affected self-esteem, and self-esteem affected self-confidence. These findings confirm that acne has a significant impact on the psychological aspects of adolescents, thus requiring special attention in efforts to improve mental health and social support.adolescents. Body image indirectly influence self-confidence through self-esteem, and self-esteem also has an indirect effect through self-confidence.
Copyright (c) 2026 Shally Ayu Chintya, Nafiah Apriliasiharta, Siti Khomsatin https://creativecommons.org/licenses/by-sa/4.0
THE RELATIONSHIP BETWEEN PERSONAL HYGIENE AND THE INCIDENCE OF PITYRIASIS VERSICOLOR IN SUKAWINATAN LANDFILL SCAVENGERS
Pityriasis versicolor is a superficial fungal skin disease and a global health concern. Scavengers working under the scorching sun with behaviors such as not showering immediately after work, rarely changing work clothes, and using damp towels are at an increased risk of developing P. versicolor. This study aimed to determine the relationship between personal hygiene and the occurrence of P. versicolor among scavengers at the Sukawinatan landfill. The research employed an analytical observational method with a cross-sectional design and total sampling technique. Forty-eight scavengers who met the inclusion and exclusion criteria were included as study subjects. Personal hygiene data were collected through questionnaires, while data on P. versicolor were obtained from clinical symptoms and examinations using a Wood's lamp. The results showed that 22.9% of the scavengers at the Sukawinatan landfill had P. versicolor. Fisher's Exact test revealed a significant relationship between personal hygiene and the occurrence of P. versicolor, with a p-value of 0.002 (p < 0.05) and a Prevalence Ratio (PR) of 5.200 (PR > 1.000). In conclusion, there is a significant relationship between personal hygiene and the occurrence of Pityriasis versicolor among scavengers at the Sukawinatan landfill.
Copyright (c) 2026 Cantika Brigitta, Susilawati, Dalilah, Gita Dwi Prasasty, Dwi Handayani https://creativecommons.org/licenses/by-sa/4.0
THE RELATIONSHIP BETWEEN SOCIOECONOMIC AND DEMOGRAPHIC FACTORS AND RHEUMATIC HEART DISEASE AT DR. SOETOMO GENERAL HOSPITAL
Rheumatic heart disease (RHD) is a public health problem, especially among low-income populations in developing countries. This study aims to examine the relationship between demographic and socioeconomic factors and the incidence of RHD at Dr. Soetomo General Hospital, Surabaya. This is an analytic study using a cross-sectional approach, with 284 respondents in 2024. Primary data were collected through questionnaires and analyzed using SPSS. The Chi-Square test revealed a significant relationship between age and RHD (p = 0.000 < 0.005), particularly among individuals aged 40-59 years. Other variables, such as gender, residential area, population density, and economic status, did not show a significant association. These findings underscore the need for targeted public health interventions specifically designed for specific age groups. Further research is recommended, utilizing larger sample sizes and a more detailed classification of RHD severity levels, to enhance prevention and disease management strategies.
Copyright (c) 2026 Kevin Ebenhaezer Silaen, Achmad Lefi, Pirlina Umiastuti, Dian Paramita Kartikasari https://creativecommons.org/licenses/by-sa/4.0
RELATIONSHIP BETWEEN BLOOD TRANSFUSION FREQUENCY AND BLOOD IRON CONCENTRATION IN PATIENT WITH THALASSEMIA MAJOR
Routine blood transfusions performed on thalassemia major patients can cause excessive iron accumulation in the body, which carries the risk of complications. Serum ferritin levels are used to assess body iron stores. This study aims to determine the correlation between transfusion frequency and iron accumulation in patients with thalassemia major. This study used a cross-sectional design with analytical observation. Data was collected by consecutive, non-random sampling from the medical records of 55 patients with thalassemia major aged 5-18 years who underwent blood transfusions at Hermina Jatinegara Hospital from January to December 2023. The independent variable was the frequency of blood transfusions per year, while the dependent variable was the average serum ferritin level, measured three times a year (every 4 months). The data obtained were analyzed using the Spearman correlation test. The results of this study found that the frequency of blood transfusions in thalassemia major patients over 1 year was 15 per year (based on the median). The average serum ferritin level was 3957.73 ng/mL (based on the median value). Spearman's correlation test showed a weak correlation between blood transfusion frequency and ferritin levels (r = 0.292; p = 0.031). The study concluded that increased blood transfusion frequency was associated with higher blood iron levels, but the correlation was weak.
Copyright (c) 2026 Vanessa Ainum Rizqita, Tjam Diana Samara https://creativecommons.org/licenses/by-sa/4.0