FACTORS ASSOCIATED WITH NEONATAL OUTCOMES IN PREMATURE RUPTURE OF MEMBRANES
Main Article Content
Keywords:
Premature rupture of membranes, Neonatal outcome, Birth weightAbstract
Premature rupture of membranes (PROM) increases the risk of maternal infection and neonatal morbidity. A cross-sectional study at Pertamedika Ummi Rosnati Hospital (July–October 2025) involved 31 pregnant women with PROM. Data included maternal age, leukocyte count, birth weight, gestational age, and infant outcomes (NICU vs. rooming-in). The mean maternal age was 29.5 years, birth weight 2682 g, and leukocyte count 13.3 thousand/μL. Infant birth weight differed significantly between the NICU (2300 g) and rooming-in (2839 g) groups (p=0.001). Preterm gestational age was associated with NICU admission (p=0.003), with 66.7% of preterm infants requiring NICU admission. Birth weight was strongly correlated with Apgar score (r=0.599; p<0.001), while maternal age and leukocyte count were not significant. Analysis indicates that birth weight and gestational age are the main factors in neonatal outcomes in PROM. Close monitoring and clinical management are needed to improve outcomes.
Article Details
References
Cunningham FG, Leveno KJ, Bloom SL, et al. Williams Obstetrics. 26th ed. New York: McGraw-Hill Education; 2022. Buku. Available from: https://accessmedicine.mhmedical.com Mercer BM. Preterm Premature Rupture of the Membranes: Current Approaches to Evaluation and Management. Obstet Gynecol Clin North Am. 2021;48(2):361–385. Jurnal. Available from: https://www.sciencedirect.com Kementerian Kesehatan Republik Indonesia. Riset Kesehatan Dasar (Riskesdas) 2023. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2023. Laporan. Available from: https://www.litbang.kemkes.go.id Dinas Kesehatan Provinsi Aceh. Profil Kesehatan Aceh 2022. Banda Aceh: Dinas Kesehatan Provinsi Aceh; 2022. Laporan. Available from: https://dinkes.acehprov.go.id Parry S, Strauss JF. Premature Rupture of the Fetal Membranes. N Engl J Med. 2021;384(16):1559–1569. Jurnal. Available from: https://www.nejm.org American College of Obstetricians and Gynecologists. Prelabor Rupture of Membranes. ACOG Practice Bulletin No. 217. Obstet Gynecol. 2020;135(3):e80–e97. Jurnal/Pedoman. Available from: https://www.acog.org Sulistyowati E, Wijaya A. Karakteristik Ibu Hamil dengan Ketuban Pecah Dini di RSUD Dr. Soetomo Surabaya. Jurnal Kebidanan Indonesia. 2020;11(2):125–132. Jurnal. Available from: https://jurnal-kebidanan-indonesia.org Perkumpulan Obstetri dan Ginekologi Indonesia (POGI). Pedoman Nasional Pelayanan Kedokteran: Ketuban Pecah Dini. Jakarta: POGI; 2021. Pedoman. Available from: https://www.pogi.or.id Blackburn ST. Maternal, Fetal, & Neonatal Physiology: A Clinical Perspective. 6th ed. St. Louis: Elsevier; 2022. Buku. Available from: https://www.elsevier.com Rahmawati D, Santoso B. Luaran Neonatal pada Ketuban Pecah Dini di RS Dr. Kariadi Semarang. Jurnal Kedokteran Diponegoro. 2019;8(4):1456–1468. Jurnal. Available from: https://ejournal3.undip.ac.id Kurniawan F, Anggraini Y, Pratama R. Maternal Leukocytosis as Predictor of Neonatal Sepsis in Premature Rupture of Membranes. Indonesian Journal of Obstetrics and Gynecology. 2021;9(1):45–52. Jurnal. Available from: https://inajog.com World Health Organization. Care of the Preterm and Low-Birth-Weight Newborn. Geneva: WHO; 2022. Buku/Pedoman. Available from: https://www.who.int Wijaya P, Sari DP, Lestari M. Faktor Risiko Perawatan NICU pada Bayi dari Ibu dengan Ketuban Pecah Dini. Sari Pediatri. 2020;22(3):178–184. Jurnal. Available from: https://saripediatri.org Gomella TL, Eyal FG, Bany-Mohammed F. Gomella’s Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs. 8th ed. New York: McGraw-Hill Education; 2020. Buku. Available from: https://accesspediatrics.mhmedical.com Santosa H, Mulyani S. Clinical Outcomes of Preterm Infants Born to Mothers with Premature Rupture of Membranes. Paediatrica Indonesiana. 2021;61(2):89–96. Jurnal. Available from: https://paediatricaindonesiana.org Aghamohammadi A, Zafari M. Maternal Age as an Independent Risk Factor for Neonatal Adverse Outcomes. J Matern Fetal Neonatal Med. 2020;33(23):3945–3951. Jurnal. Available from: https://www.tandfonline.com Lawn JE, Ohuma EO, Bradley E, et al. Small Babies, Big Risks: Global Estimates of Prevalence and Mortality for Vulnerable Newborns to Accelerate Change and Improve Counting. Lancet. 2023;401(10389):1707–1719. Jurnal. Available from: https://www.thelancet.com Van Smeden M, Moons KGM, de Groot JAH, Collins GS, Altman DG, Eijkemans MJC, Reitsma JB. Sample size for binary logistic prediction models: Beyond events per variable criteria. Stat Methods Med Res. 2019;28(8):2245–2474.
