QUALITY OF LIFE OF CENTRAL NERVOUS SYSTEM TUMOR PATIENTSWITH CANCER PAIN
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Keywords:
Cancer Pain, Quality of Life, Central Nervous System, Tumors, EORTC QLQ-C30, NPRSAbstract
Cancer pain is the main symptom experienced by patients with central nervous system (CNS) tumors and significantly affects quality of life. A cross-sectional study at Dr. Mohammad Hoesin General Hospital, Palembang (March–June 2025) involved 89 patients using consecutive sampling. Data were obtained from medical records and structured interviews. Quality of life was assessed using the EORTC QLQ-30, while pain intensity was assessed using the NPRS. The majority of patients were female (56.2%), aged <60 years (75.3%), with secondary (55.1%) and intracranial (76.4%) tumors. Most experienced mild pain (56.2%) and received non-opioid therapy (70.8%). Results showed a moderate quality of life, with relatively high cognitive function, but pain intensity was negatively correlated with quality of life (r = -0.321; p = 0.002). Severe pain increased the risk of poor quality of life 4.7-fold, while tumor type increased the risk 5.1-fold. These findings confirm that effective pain management, appropriate analgesic selection, and definitive therapy play an important role in improving the quality of life of CNS tumor patients.
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References
Rodriguez C, Ji M, Wang HL, Padhya T, Mcmillan SC. Cancer Pain and Quality of Life. J Hosp Palliat Nurs. 2019 Apr 1;21(2):116–23.
Carlson CL. Effectiveness of the World Health Organization cancer pain relief guidelines: An integrative review. Vol. 9, Journal of Pain Research. Dove Medical Press Ltd.; 2016. p. 515–34.
Perwitasari DA, Purba FD, Candradewi SF, Dania H, Muhammad Irham L, Noor Faridah I, et al. Quality of Life of Cancer Patients during Chemotherapy in Indonesia: A Comparison of EORTC QLQ-C30 and EQ-5D-5L, Based on Patients’ Characteristics. Int J Clin Pract. 2023;2023.
Miret C, Orive M, Sala M, García-Gutiérrez S, Sarasqueta C, Legarreta MJ, et al. Reference values of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L for women with non-metastatic breast cancer at diagnosis and 2 years after. Qual Life Res. 2023;32(4):989–1003.
Cocks K, Wells JR, Johnson C, Schmidt H, Koller M, Oerlemans S, et al. Content validity of the EORTC quality of life questionnaire QLQ-C30 for use in cancer. Eur J Cancer. 2023 Jan 1;178:128–38.
Angela D, Ardiansyah D, Agung Suprabawati DG. Hubungan intensitas nyeri dengan kualitas hidup pasien kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo. Intisari Sains Medis. 2022 Feb 28;13(1):109–16.
Penelitian A, Puspa R, Wibisono Y, Sadeli HA. Penilaian Kualitas Hidup Eortc Qlq-C30 Dan Eortc Qlq-Bn20 Pada Pasien Tumor Primer Intrakranial Pascaterapi. Vol. 35. 2018.
Rafli R, Anissa M. Peningkatan kualitas hidup pasien kanker dengan metastasis tulang yang menjalani radiasi paliatif. Maj Kedokt Andalas. 2019 Jan 31;42(1):1.
van der Vliet QMJ, Paulino Pereira NR, Janssen SJ, Hornicek FJ, Ferrone ML, Bramer JAM, et al. What Factors are Associated With Quality Of Life, Pain Interference, Anxiety, and Depression in Patients With Metastatic Bone Disease? Clin Orthop Relat Res. 2017;475(2):498–507.
Diansari Y, Syafiera H, Anggraeni D, Asfitriani A. Karakteristik Tumor Sistem Saraf Pusat di RSUP Dr. Mohammad Hoesin Palembang. J Kedokt dan Kesehat Publ Ilm Fak Kedokt Univ Sriwij. 2022 May 9;9(2):123–32.
Snijders RAH, Brom L, Theunissen M, van den Beuken-van Everdingen MHJ. Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis. Vol. 15, Cancers. MDPI; 2023.
Wiffen PJ, Wee B, Derry S, Bell RF, Moore RA. Opioids for cancer pain - an overview of Cochrane reviews. Cochrane Database of Systematic Reviews. 2017.
Liu D, Weng J Sen, Ke X, Wu XY, Huang ST. The relationship between cancer-related fatigue, quality of life and pain among cancer patients. Int J Nurs Sci. 2023;10(1):111–6.
Couceiro TC de M, Lima LC, Coutinho Júnior MP, Mello PF da LS de O, Ferreira TMML, Firmino ALP. Prevalence of neuropathic pain in patients with cancer. Brazilian J Pain. 2018;1(3):231–5.
Is TP, Part K, Treatment C. Pain management for patients with cancer. CA Cancer J Clin. 2018;68(3):197–8.
Swarm RA, Paice JA, Anghelescu DL, Are M, Bruce JY, Buga S, et al. Adult cancer pain, version 3.2019. JNCCN J Natl Compr Cancer Netw. 2019;17(8):977–1007.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.
Stockdill ML, Mendoza T, Armstrong TS, Miaskowski C, Cooper B, Vera E. Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors. J Neurooncol [Internet]. 2023;165(1):181–90. Available from: https://doi.org/10.1007/s11060-023-04474-5
Haider S, Taphoorn MJB, Drummond KJ, Walbert T. Health-related quality of life in meningioma. Neuro-Oncology Adv. 2021;3(1):1–9.
Aman MM, Mahmoud A, Deer T, Sayed D, Hagedorn JM, Brogan SE, et al. The American Society of Pain and Neuroscience (ASPN) best practices and guidelines for the interventional management of cancer-associated pain. J Pain Res. 2021;14:2139–64.
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