CORRELATION OF APOLIPOPROTEIN B LEVELS WITH THE DEGREE OF CORONARY ARTERY STENOSIS IN CHRONIC CORONARY SYNDROME PATIENTS

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Authors

Muhammad Novran Chalik
Erwin Sukandi
Irfannuddin
Syamsu Indra
Zen Ahmad
Keywords:
Chronic coronary Syndrome, SYNTAX Score, Degree of arterial stenosis, Atherosclerosis

Abstract

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Apolipoproteins are structural components of plasma lipoproteins that involved in lipoprotein metabolism and lipid transport, reflect the number of circulating atherogenic particles. This study aims to investigate the correlation between serum apolipoprotein B levels and the degree of coronary artery stenosis in patients with chronic coronary syndrome. A cross-sectional study design was used, involving 34 patients selected from a total population of 69 individuals. Data were collected from July 2024 to September 2024. The results showed that most respondents had elevated apolipoprotein B levels, with a mean value of 141.41 ± 25.06 mg/dL, and SYNTAX score of ≥ 23, with a mean value of 24.09 ± 2.69. Pearson’s correlation test indicated a significant relationship between apolipoprotein B levels and SYNTAX scores (p = 0.029, r = 0.376). Multivariate analysis revealed a significant p-value for apolipoprotein B (p = 0.017) with a positive regression coefficient.

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References

Neumann FJ, Sechtem U, Banning AP, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41(3):407-477. doi:10.1093/eurheartj/ehz425

Virani SS, Newby LK, Arnold SV, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease. J Am Coll Cardiol. 2023;82(9):833-955. doi:10.1016/j.jacc.2023.04.003

Kementrian Kesehatan Republik Indonesia. Hari Jantung Sedunia (HJS) Tahun 2019: Jantung Sehat, SDM Unggul. 2019.

Dinas Kesehatan Provinsi Sumatera Selatan. Pemprov Sumsel bersama YJI sosialisasikan upaya pencegahan kardiovaskuler. Published online 2022. https://dinkes.sumselprov.go.id/2022/10/pemprov-sumsel-bersama-yji-sosialisasikan-upaya-pencegahan-kardiovaskuler/

Kim BK, Hong SJ, Lee YJ. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2022;32(8-9):381-383. doi:10.1093/eurheartj/ehz455

Glavinovic T, Thanassoulis G, de Graaf J, Couture P, Hegele RA, Sniderman AD. Physiological Bases for the Superiority of Apolipoprotein B Over LDL-C and Non–HDL-C as a Marker of Cardiovascular Risk. J Am Heart Assoc. 2022;11(20):1-17. doi:10.1161/JAHA.122.025858

Behbodikhah J, Ahmed S, Elyasi A, et al. Apolipoprotein B and cardiovascular disease: Biomarker and potential therapeutic target. Metabolites. 2021;11(10). doi:10.3390/metabo11100690

Devaraj S, Semaan JR JI. Biochemistry, Apolipoprotein B. In: StatPearls. Treasure Island (FL): StatPearls. Published online 2023.

Yammine M, Itagaki S, Pawale A, Toyoda N, Reddy RC. SYNTAX score may predict the severity of atherosclerosis of the ascending aorta. J Thorac Dis. 2017;9(10):3859-3865. doi:10.21037/jtd.2017.09.17

Muszyński P, Pawluczuk E, Pasławska M, et al. Sex-Related Differences in Risk Factors and Management of Chronic Coronary Syndrome. J Clin Med. 2023;12(23). doi:10.3390/jcm12237320

AlRashed M, Rajan R, Al-Jarallah M, et al. Gender Differences in Coronary Profiles of Chronic Coronary Syndrome Patients. Ann Clin Cardiol. 2022;4(1):20-26. doi:10.4103/accj.accj_16_21

Gao Z, Chen Z, Sun A, Deng X. Gender differences in cardiovascular disease. Med Nov Technol Devices. 2019;4:100025. doi:10.1016/j.medntd.2019.100025

Ambrosini AP, Fishman ES, Damluji AA, Nanna MG. Chronic Coronary Disease in Older Adults. Med Clin North Am. 2024;108(3):581-594. doi:10.1016/j.mcna.2023.12.004

Salimi A, Zolghadrasli A, Jahangiri S, et al. Potential of HEART score to detect severity of CAD according to SYNTAX score. Sci Rep. 2023;13(1):1-7. doi:10.1038/s41598-023-34213-9

Zhao D, Wang Y, Wong ND, Wang J. Impact of Aging on Cardiovascular Diseases. JACC Asia. 2024;4(5):345-358. doi:10.1016/j.jacasi.2024.02.002

Gariepy J, Denarie N, Chironi G, Salomon J, Levenson J, Simon A. Gender difference in smoking influence on arterial wall thickness. Atherosclerosis. 2000;153(1):139-145. doi:10.1016/S0021-9150(00)00382-8

Kiriyama H, Kaneko H, Itoh H, et al. Effect of cigarette smoking on carotid artery atherosclerosis. Heart Vessels. 2020;35(1):22-29. doi:10.1007/s00380-019-01455-5

Mathiesen EB, Johnsen SH, Wilsgaard T, et al. Carotid plaque area and intima-media thickness in prediction of ischemic stroke: Tromsø study. Stroke. 2011;42(4):972-978. doi:10.1161/STROKEAHA.110.589754

Morelli M, Tognola C, Garofani I, et al. Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients. High Blood Press Cardiovasc Prev. 2025;32(3):335-341. doi:10.1007/s40292-025-00718-9

Boden WE, Rourke RA, Maron DJ, et al. Optimal Medical Therapy with or without PCI for Stable Coronary Disease. Published online 2014:1503-1516.

Aronson D, Rayfield EJ. How hyperglycemia promotes atherosclerosis: Molecular mechanisms. Cardiovasc Diabetol. 2002;1:1-10. doi:10.1186/1475-2840-1-1

Akhtaruzzaman M, Ahmed M, Hossain M, et al. Effect of dyslipidemia and its association with CAD on angiographic findings. Med Res Chronicles. 2022;9(5):327-336. https://medrech.com/index.php/medrech/article/view/602

Lind L, Markstad H, Ahlstrom H, Angeras O, Brandberg J, Brunstrom M. Obesity and coronary artery stenosis: SCAPIS study. Elsevier. 2022;362:1-10. doi:10.1016/S1015-9584(09)60326-2

Zheng C, Liu Y, Xu C, et al. Association between obesity and dyslipidemia in middle-aged and older people. Sci Rep. 2024;14(1):1-11. doi:10.1038/s41598-024-62892-5

Stapleton PA, James ME, Goodwill AG, Frisbee JC. Obesity and vascular dysfunction. Pathophysiology. 2008;15(2):79-89. doi:10.1016/j.pathophys.2008.04.007

Ravnskov U, de Lorgeril M, Diamond DM, et al. LDL-C does not cause cardiovascular disease: review. Expert Rev Clin Pharmacol. 2018;11(10):959-970. doi:10.1080/17512433.2018.1519391

Ference BA, Bhatt DL, Catapano AL, et al. Genetic Variants and Lifetime Risk of Cardiovascular Disease. JAMA. 2019;322(14):1381-1391. doi:10.1001/jama.2019.14120

Inoue H, Shiga Y, Tashiro K, et al. LDL-C and coronary atherosclerosis via CT angiography. Cardiol Res. 2021;12(1):10-15. doi:10.14740/cr1180

Packard CJ, Boren J, Taskinen MR. Causes and Consequences of Hypertriglyceridemia. Front Endocrinol. 2020;11:1-15. doi:10.3389/fendo.2020.00252

Lin T, Wang L, Guo J, et al. Association Between Serum LDL-C and ApoB and SYNTAX Score. Angiology. 2018;69(8):724-729. doi:10.1177/0003319717748771

Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: Mendelian randomisation study. Lancet. 2012;380(9841):572-580. doi:10.1016/S0140-6736(12)60312-2

Schwartz GG, Olsson AG, Abt M, et al. Effects of Dalcetrapib in Patients with Acute Coronary Syndrome. N Engl J Med. 2012;367(22):2089-2099. doi:10.1056/nejmoa1206797

Darmawan H, Irfanuddin. Effect of age and sex on lipid profile and obesity among telecom workers in Palembang. Med J Indones