Caesalpinia bonducella contain flavonoid, tanin, saponin which has antidiabetic activity. The aim of this study was to
determine that the Caesalpinia bonducella seed extract orally reduces post-prandial blood glucose level and prevent the
reduction of fasting insulin level in diabetic male albino rats (Rattus norvegicus). This study was a true experimental
with pre-test post-test control group design using 24 male albino rats. All samples were induced with streptozotocin
which caused the destruction of β cell and nicotinamide which protected the β cell from destructions of that the
pancreatic β-cell was not destructed entirely. The selected samples were divided into three groups: the control negative
group was given distilled water (P0), the control positive group was given glibenclamide (P1), and the treatment group
was given ethanolic extracts of Caesalpinia bonducella seed 500mg/kg body weight (P2). Blood glucose and plasma
insulin measurements were taken after 14 days of treatment. The result showed that the post-prandial blood glucose
level of treatment group (P2) was decreased significantly, from 232,63±10,31 mg/dl to 185,50±16,00 mg/dl (P<0.001)
whereas in P0 group, post-prandial blood glucose level was rising significantly from 223,75±17.03 mg/dl to
267,25±17,56 mg/dl (p<0.001). In P1 group, the reduction of post-prandial blood glucose level was bigger compare to
P2 group, which was from 228,50±11,55 mg/dl to 115,88±10,23 mg/dl (p<0.001). Post test fasting insulin level of P2
group was significantly different compare to other group (p<0.05). The administration of Caesalpinia bonducella seed
extract increased the fasting insulin level although did not significant statistically (p>0.05) whereas the other group
showed the reduction of fasting insulin level (p<0.05). It can be concluded that the administration of Caesalpinia
bonducella seed extract orally reduced post-prandial blood glucose level and prevent reduction of fasting plasma insulin
level in diabetic male albino rats.