THE QUALITY OF SLEEP IN BRAIN TUMOR PATIENTS
Main Article Content
The Quality of Sleep in Brain Tumors Patients. Sleep quality is often compromised in patients with brain tumors. The underlying factors contributing to sleep quality disturbances in this patient population are multifaceted, and investigating these factors remains scarce. Sixty-eight patients with brain tumors, aged ≥ 18 years, were selected consecutively, and data was recorded in the form of sociodemographic characteristics (gender and age), clinical characteristics (clinical manifestations, tumor type, location, comorbid diseases) and therapy characteristics (management and types of drugs). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data were analyzed bivariate with chi-square and multivariate with logistic regression. Around 45.6% experienced poor sleep quality. Age, gender, systemic malignancies, pain, type of primary brain tumor, tumor location, operation, radiotherapy, and steroid have a significant relationship with sleep quality in patients with brain tumors (p-value <0.05). Multivariate analysis shows that age is the factor that most strongly influences the sleep quality of patients with brain tumors. Age, gender, systemic malignancies, pain, type of primary brain tumor, tumor location, operative treatment, radiotherapy, and steroids influence the quality of sleep in patients with brain tumors, but age has the most decisive influence.
2. Cheng JX, Liu BL, Zhang X, Lin W, Zhang YQ. et al. Health-related quality of life in gliomapatients in China. BMC Cancer 2010;10:305. Available from: https://pubmed.ncbi.nlm.nih.gov/20565883
3. Wardah RI. 2018. Panduan Tatalaksana Gangguan Tidur. Jakarta : Sagung Seto Astri Y, Hakim M, Aninditha T, Renindra AA, Budikayanti A. Gambaran Arsitektur Pada Pasien Tumor Otak Yang Mengalami Gangguan Tidur. Neurona. 2021;38(2) Available from: ejournal.neurona.web.id › index › neurona
4. Astri Y, Hakim M, Aninditha T, Renindra AA, Budikayanti A. Gambaran Arsitektur Pada Pasien Tumor Otak Yang Mengalami Gangguan Tidur. Neurona. 2021;38(2). Available from: ejournal.neurona.web.id › index › neurona
5. Lin PC, Chen PY, Wei KC, Lin JH, Lin MR, Wang HC, Chiu HY. Sleep Disturbance in Adults With Untreated Primary Brain Tumors : Prevalence and Effect On Quality Of Life. Research Square. 2022:1- 18. Available from: https://pubmed.ncbi.nlm.nih.gov/38469283/
6. Willis KD, Ravyts SG, gugue LM, Loughan AR. Sleep Disturbance In Primary Brain Tumor : Prevalence, risk Factors and Patien Preferences. Supportive Care In cancer. 2022;20:741-748. Available from: pubmed.ncbi.nlm.nih.gov › 34368887
7. Jeon MS, Dhillon HM, Koh ES, Nowak AK, Hovey E, Descallar J, Miller S, Marshal NS, Agar MR. Sleep disturbance among adults with primary and secondary malignant brain tumors. Doi:10.1093/nop/npaa057.2021; 8(1):48-59. Available from: www.ncbi.nlm.nih.gov › pmc › articles
8. Silva A. Gender and age differences in polysomnography findings and sleep complaints of patients reffered to a leep laboratory. Braz J Med Biol Res. 2008:41(12):1067-75. Available from: pubmed.ncbi.nlm.nih.gov › 19148368
9. Peng Y, Shao C, Gong Y, Wu X, Tang W, Shi S. Relationship between apathy and tumor location, size and brain edema in patients with intracranial meningioma. Neuropsy Dis. 2015;11:1185-93. Available from: pubmed.ncbi.nlm.nih.gov › 26203250
10. Eban R, Appelbaum L, de Lecea L. Neuronal mechanisms for sleep/wake regulation and modulatory drive. 2018;43:937-52. Available from: www.nature.com › articles › npp2017294
11. Pablo T, Jaime M, Pandi PSR. Neuroanatomy and Neuropharmacology of Sleep and wakefulness in Synopsis of Sleep Medicine. Apple Academy Press. 2017. P1-22. Available from : pubmed.ncbi.nlm.nih.gov › 21278831
12. Powell C, Guerrero D, sardell S et al. Somnolence syndrome in patient receiving radical radiotherapy for primary brain tumours: a prospective study. Radiotheraphy and oncology: journal of the European Society fot Therapeutic Radiology and Oncology. 2011;100(1):131-136. Available from : pubmed.ncbi.nlm.nih.gov › 21782266
13. Wang Zi-Jung et al. Glucpcorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment. Sci Reports. 2015;5:1-11. Available from: www.nature.com › articles › srep09442
14. Ohayon B, Brinne M et al. Sleep in the aging population. Sleep Med Clin. 2017;12(1):31-8. Available from: pubmed.ncbi.nlm.nih.gov › 28159095
15. Mainio C, day J et al. Fatigue and associated symptoms in patients with primary brain tumor. Annals of Clinical Oncology. 2019;2(3):1-9. Available from: https://sciencerepository.org/fatigue-and-associated-symptoms-in-patients-with-a-primary-brain-tumor_ACO-2019-3-104
16. Huang Y, Jiang ZJ, Deng J, Qi YJ. Sleep quality of patients with postoperative glioma at home. World J Clin Cases. 2020;8(20):4735–42. Available from: pubmed.ncbi.nlm.nih.gov › 33195641
17. Jeon MS, Dhillon HM, Agar MR. Sleep disturbance of adults with a brain tumor and their family caregivers: a systematic review. Doi:10.1093/neuonc/nov019. 2017; 19(8):1035-1046. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5570226
18. Ohayon B, Brinne M et al. Sleep in the aging population. Sleep Med Clin. 2017;12(1):31-8. Available from https://pubmed.ncbi.nlm.nih.gov/28159095/
19. Mainio C, day J et al. Fatigue and associated symptoms in patients with primary brain tumor. Annals of Clinical Oncology. 2019;2(3):1-9. Available from https://pmc.ncbi.nlm.nih.gov/articles/PMC6047436/
20. Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000; 284:861–868. doi: 10.1001/jama.284.7.861.Available from https://pubmed.ncbi.nlm.nih.gov/10938176/