ISCHEMIA-MODIFIED ALBUMIN (IMA) AS A BIOMARKER OF OXIDATIVE STRESS IN PREGNANCY
Main Article Content
This study aims to determine IMA levels as a marker of oxidative stress that occurs in ectopic pregnancy and preeclampsia. The method of this study is screening using secondary data obtained from literature searches found in national and international journals, with the keywords 'Oxidative Stress' or 'IMA' and 'Pregnancy'. Articles are included in the inclusion criteria if they are published in national or international journals with topics in accordance with the research objectives in the period 2014 - 2024, full-text access, both in English and Indonesian. It was found that serum IMA levels were increased in preeclampsia and, In comparison to normal pregnancy, ectopic pregnancy. This literature study concludes that IMA can be a biomarker for pregnancy-related diseases, especially preeclampsia and ectopic pregnancy. Higher sensitivity and specificity results in preeclampsia compared to ectopic pregnancy, the IMA test is better used to identify preeclampsia compared to ectopic pregnancy.
Keywords:
Oxidative stress
IMA
Pregnancy
1. Rush JWE, Denniss SG, Graham DA. Vascular Nitric Oxide and Oxidative Stress: Determinants of Endothelial Adaptations to Cardiovascular Disease and to Physical Activity [Internet]. J. Appl. Physiol. Downloaded from www.nrcresearchpress.com by. 2005. Available from: www.nrcresearchpress.com
2. Nagawa Tamale B, Bulafu D, Bosco Isunju J, Vicky Jamu A, Natweta Baguma J, Tigaiza A, et al. Pregnancy-related complications and associated factors among women attending antenatal care at a specialised maternal and child health national referral hospital, in Uganda. 2022; Available from: https://doi.org/10.1101/2022.07.29.22278187
3. Kumar V, Gupta J. Tubal ectopic pregnancy. BMJ Clin Evid [Internet]. 2015;2015. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26571203
4. Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, et al. Role of oxidative stress and antioxidant supplementation in pregnancy disorders. In: American Journal of Clinical Nutrition. 2011.
5. Bahinipati J, Mohapatra PC. Ischemia modified albumin as a marker of oxidative stress in normal pregnancy. Journal of Clinical and Diagnostic Research. 2016 Sep 1;10(9):BC15–7.
6. Bozkaya G, Karaca I, Fenercioglu O, Yildirim Karaca S, Bilgili S, Uzuncan N. Evaluation of maternal serum ischemia modified albumin and total antioxidant status in ectopic pregnancy. Journal of Maternal-Fetal and Neonatal Medicine. 2019 Jun 18;32(12):2003–8.
7. Chiarello DI, Abad C, Rojas D, Toledo F, Vázquez CM, Mate A, et al. Oxidative stress: Normal pregnancy versus preeclampsia. Vol. 1866, Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020.
8. Subandrate, Faisal ME, Anggraini NW. Peranan Stres Oksidatif pada Preeklampsia [Internet]. Vol. 44. Palembang; 2017. Available from: http://www.who.
9. Dogan K, Helvacioglu C, Baghaki S, Kural A, Dogan M. Ischemia-Modified Albumin (IMA) levels in ectopic pregnancy and early pregnancy loss. Niger J Clin Pract. 2022 Jul 1;25(7):975–8.
10. Jaiswar SP, Verma S, Agrawal M, Deo S, Goel M, Mahdi AA. Association of Maternal Serum Ischemia Modified Albumin (IMA) with Placental Histopathological Changes and Fetomaternal Outcome: A Prospective Case Control Study in Normotensive and Pre-eclamptic Women. Journal of Obstetrics and Gynecology of India. 2022 Aug 1;72:166–73.
11. Üreyen Özdemir E, Yalçın Bahat P, Topbaş Selçuki NF, Çakmak K, Çakmak F, Neşelioğlu S, et al. Evaluation of Oxidative Stress in Ectopic Pregnancies. Acta Biomed. 2022 Mar 14;93(1):e2022025.
12. Karaśin SS, Çift T. The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia. Revista Brasileira de Ginecologia e Obstetricia. 2020 Mar 1;42(3):133–9.
13. Sulaiman S, Al-Bayati M. Ischemia Modified Albumin in Maternal Serum and Cord Blood in Relation to Preeclampsia Severity and Neonatal Outcome. Iraqi Postgraduate Medical Journal. 2023 Oct 1;22:372–8.
14. Burton GJ, Jauniaux E. Oxidative stress. Best Pract Res Clin Obstet Gynaecol [Internet]. 2010;25(3):287–99. Available from: http://dx.doi.org/10.1016/j.bpobgyn.2010.10.016
15. Grewal P. Pregnancy-Related Liver Disease. In: Mount Sinai Expert Guides: Hepatology [Internet]. 2014. p. 271–9. Available from: https://doi.org/10.1002/9781118748626.ch25
16. ACOG A. Hypertension in pregnancy. Obstet Gynecol. 2013;122(5):1122–31.
17. Bar-Or D, Lau E, Winkler J V. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med. 2000 Nov;19(4):311–5.
18. Creanga AA, Syverson C, Seed K, Callaghan WM. Pregnancy-Related Mortality in the United States, 2011-2013. Obstetrics and gynecology [Internet]. 2017;130(2):366–73. Available from: http://dx.doi.org/10.1097/AOG.0000000000002114
19. Idrees M, Oh SH, Muhammad T, El-Sheikh M, Song SH, Lee KL, et al. Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development. Cells [Internet]. 2020;9(8). Available from: https://www.mdpi.com/2073-4409/9/8/1798
20. Guérin P, El Mouatassim S, Ménézo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update [Internet]. 2001;7(2):175–89. Available from: http://dx.doi.org/10.1093/humupd/7.2.175
21. Shao R, Zhang SX, Weijdegård B, Zou S, Egecioglu E, Norström A, et al. Nitric oxide synthases and tubal ectopic pregnancies induced by Chlamydia infection: basic and clinical insights. Mol Hum Reprod [Internet]. 2010;16(12):907–15. Available from: http://dx.doi.org/10.1093/molehr/gaq063
22. Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, Ulusoy H, et al. Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Academic Emergency Medicine. 2009;16(6).
23. Shevtsova A, Gordiienko I, Tkachenko V, Ushakova G. Ischemia-Modified Albumin: Origins and Clinical Implications. Dis Markers [Internet]. 2021 [cited 2024 Aug 10];2021. Available from: /pmc/articles/PMC8315882/
24. Dulger O, Basaran B, Korkusuz M, Erel O, Neselioglu S, Osmanoglu UO, et al. The Effect of Preoperative Carbohydrate-containing Fluid Consumption on Maternal Oxidative Stress Markers During Elective Cesarean Delivery. Journal of PeriAnesthesia Nursing [Internet]. 2024; Available from: https://www.sciencedirect.com/science/article/pii/S1089947224000522
25. Yoshimatsu J. World Congress of Perinatal Medicine. 2021;49(6):eA1–54. Available from: https://doi.org/10.1515/jpm-2021-0310
26. Vafaei H, Karimi Z, Akbarzadeh-Jahromi M, Asadian F. Association of placental chorangiosis with pregnancy complication and prenatal outcome: a case-control study. BMC Pregnancy Childbirth [Internet]. 2021;21(1):99. Available from: https://doi.org/10.1186/s12884-021-03576-0
27. Çobanoğlu U, Birge Ö, Çetin M, Güven ESG. Evaluation of Maternal Ischemia-Modified Albumin Levels during Pregnancy and Their Effect on Fetal Birth Weight. Medicina (B Aires) [Internet]. 2024;60(9). Available from: https://www.mdpi.com/1648-9144/60/9/1530
2. Nagawa Tamale B, Bulafu D, Bosco Isunju J, Vicky Jamu A, Natweta Baguma J, Tigaiza A, et al. Pregnancy-related complications and associated factors among women attending antenatal care at a specialised maternal and child health national referral hospital, in Uganda. 2022; Available from: https://doi.org/10.1101/2022.07.29.22278187
3. Kumar V, Gupta J. Tubal ectopic pregnancy. BMJ Clin Evid [Internet]. 2015;2015. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26571203
4. Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, et al. Role of oxidative stress and antioxidant supplementation in pregnancy disorders. In: American Journal of Clinical Nutrition. 2011.
5. Bahinipati J, Mohapatra PC. Ischemia modified albumin as a marker of oxidative stress in normal pregnancy. Journal of Clinical and Diagnostic Research. 2016 Sep 1;10(9):BC15–7.
6. Bozkaya G, Karaca I, Fenercioglu O, Yildirim Karaca S, Bilgili S, Uzuncan N. Evaluation of maternal serum ischemia modified albumin and total antioxidant status in ectopic pregnancy. Journal of Maternal-Fetal and Neonatal Medicine. 2019 Jun 18;32(12):2003–8.
7. Chiarello DI, Abad C, Rojas D, Toledo F, Vázquez CM, Mate A, et al. Oxidative stress: Normal pregnancy versus preeclampsia. Vol. 1866, Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020.
8. Subandrate, Faisal ME, Anggraini NW. Peranan Stres Oksidatif pada Preeklampsia [Internet]. Vol. 44. Palembang; 2017. Available from: http://www.who.
9. Dogan K, Helvacioglu C, Baghaki S, Kural A, Dogan M. Ischemia-Modified Albumin (IMA) levels in ectopic pregnancy and early pregnancy loss. Niger J Clin Pract. 2022 Jul 1;25(7):975–8.
10. Jaiswar SP, Verma S, Agrawal M, Deo S, Goel M, Mahdi AA. Association of Maternal Serum Ischemia Modified Albumin (IMA) with Placental Histopathological Changes and Fetomaternal Outcome: A Prospective Case Control Study in Normotensive and Pre-eclamptic Women. Journal of Obstetrics and Gynecology of India. 2022 Aug 1;72:166–73.
11. Üreyen Özdemir E, Yalçın Bahat P, Topbaş Selçuki NF, Çakmak K, Çakmak F, Neşelioğlu S, et al. Evaluation of Oxidative Stress in Ectopic Pregnancies. Acta Biomed. 2022 Mar 14;93(1):e2022025.
12. Karaśin SS, Çift T. The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia. Revista Brasileira de Ginecologia e Obstetricia. 2020 Mar 1;42(3):133–9.
13. Sulaiman S, Al-Bayati M. Ischemia Modified Albumin in Maternal Serum and Cord Blood in Relation to Preeclampsia Severity and Neonatal Outcome. Iraqi Postgraduate Medical Journal. 2023 Oct 1;22:372–8.
14. Burton GJ, Jauniaux E. Oxidative stress. Best Pract Res Clin Obstet Gynaecol [Internet]. 2010;25(3):287–99. Available from: http://dx.doi.org/10.1016/j.bpobgyn.2010.10.016
15. Grewal P. Pregnancy-Related Liver Disease. In: Mount Sinai Expert Guides: Hepatology [Internet]. 2014. p. 271–9. Available from: https://doi.org/10.1002/9781118748626.ch25
16. ACOG A. Hypertension in pregnancy. Obstet Gynecol. 2013;122(5):1122–31.
17. Bar-Or D, Lau E, Winkler J V. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med. 2000 Nov;19(4):311–5.
18. Creanga AA, Syverson C, Seed K, Callaghan WM. Pregnancy-Related Mortality in the United States, 2011-2013. Obstetrics and gynecology [Internet]. 2017;130(2):366–73. Available from: http://dx.doi.org/10.1097/AOG.0000000000002114
19. Idrees M, Oh SH, Muhammad T, El-Sheikh M, Song SH, Lee KL, et al. Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development. Cells [Internet]. 2020;9(8). Available from: https://www.mdpi.com/2073-4409/9/8/1798
20. Guérin P, El Mouatassim S, Ménézo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update [Internet]. 2001;7(2):175–89. Available from: http://dx.doi.org/10.1093/humupd/7.2.175
21. Shao R, Zhang SX, Weijdegård B, Zou S, Egecioglu E, Norström A, et al. Nitric oxide synthases and tubal ectopic pregnancies induced by Chlamydia infection: basic and clinical insights. Mol Hum Reprod [Internet]. 2010;16(12):907–15. Available from: http://dx.doi.org/10.1093/molehr/gaq063
22. Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, Ulusoy H, et al. Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Academic Emergency Medicine. 2009;16(6).
23. Shevtsova A, Gordiienko I, Tkachenko V, Ushakova G. Ischemia-Modified Albumin: Origins and Clinical Implications. Dis Markers [Internet]. 2021 [cited 2024 Aug 10];2021. Available from: /pmc/articles/PMC8315882/
24. Dulger O, Basaran B, Korkusuz M, Erel O, Neselioglu S, Osmanoglu UO, et al. The Effect of Preoperative Carbohydrate-containing Fluid Consumption on Maternal Oxidative Stress Markers During Elective Cesarean Delivery. Journal of PeriAnesthesia Nursing [Internet]. 2024; Available from: https://www.sciencedirect.com/science/article/pii/S1089947224000522
25. Yoshimatsu J. World Congress of Perinatal Medicine. 2021;49(6):eA1–54. Available from: https://doi.org/10.1515/jpm-2021-0310
26. Vafaei H, Karimi Z, Akbarzadeh-Jahromi M, Asadian F. Association of placental chorangiosis with pregnancy complication and prenatal outcome: a case-control study. BMC Pregnancy Childbirth [Internet]. 2021;21(1):99. Available from: https://doi.org/10.1186/s12884-021-03576-0
27. Çobanoğlu U, Birge Ö, Çetin M, Güven ESG. Evaluation of Maternal Ischemia-Modified Albumin Levels during Pregnancy and Their Effect on Fetal Birth Weight. Medicina (B Aires) [Internet]. 2024;60(9). Available from: https://www.mdpi.com/1648-9144/60/9/1530
