EFFECT OF MORINGA (Moringa oleifera) LEAF FLOUR ETHANOL EXTRACT ON REDUCTION OF BLOOD GLUCOSE IN MALE WISTAR STRAIN RATS INDUCED BY ALLOXAN
Main Article Content
This study is to determine the effect of giving ethanol extract of moringa leaf flour (Moringa oleifera) on reducing blood glucose levels of alloxan-induced Wistar Rattus norvegicus male rats. Using a true experimental design with a randomized pre and post control group approach. The sample used consisted of 35 male Wistar white rats. Data collection using simple random sampling technique. Paired t test gives the results of p<0.05 in all treatment groups, meaning that there are differences in fasting blood glucose levels of hyperglycemic rats before and after treatment. One way ANOVA test gave the result of p<0.001, meaning that all treatment groups showed a significant difference in the mean difference in fasting blood glucose levels before and after treatment. LSD post hoc test results showed a significant mean difference in fasting blood glucose levels before and after treatment of P1 and P2 with all treatment groups (p<0.001). Probit analysis test obtained ED50=1447,84 mg/kgBB.
Keywords:
Diabetes
Tepung Daun Kelor
Moringa oleifera
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Owens III FS, Dada O, Cyrus JW, Adedoyin OO, Adunlin G. The effects of Moringa oleifera on blood glucose levels: a scoping review of the literature. Complement Ther Med. 2020;50:102362.
Hu S, Wang L, Togo J, Yang D, Xu Y, Wu Y, et al. The carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of mice. Mol Metab. 2020;32:27–43.
Schleicher E, Gerdes C, Petersmann A, Müller-Wieland D, Müller UA, Freckmann G, et al. Definition, classification and diagnosis of diabetes mellitus. Experimental and Clinical Endocrinology & Diabetes. 2022;130(S 01):S1–8.
Alp H, Sahin A, Karabaglı P, Karaburgu S, Yılmaz Sanal B, Yuksel EB. Current perspective on diabetes mellitus in clinical sciences. Nobel Tıp Bookstores; 2023.
Badan Penelitian dan Pengembangan Kesehatan KKRI. Hasil Utama Riser Kesehatan Dasar [Internet]. https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf. 2018 [cited 2024 Feb 1]. Available from: https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf
Pemerintah Kota Bandar Lampung Dinas Kesehatan. Profil Kesehatan Kota Bandar Lampung 2022. https://bandarlampungkota.go.id/new/dokumen/989-Profil%20Kesehatan%202022.pdf. 2023.
González P, Lozano P, Ros G, Solano F. Hyperglycemia and oxidative stress: An integral, updated and critical overview of their metabolic interconnections. Int J Mol Sci. 2023;24(11):9352.
Afrianti R. Pengaruh Pemberian Fraksi Etilasetat Kulit Ubi Jalar Ungu Terhadap Kadar Malondialdehid (Mda) Serum Mencit Putih Jantan Hiperglikemia. Scientia : Jurnal Farmasi dan Kesehatan. 2018 Sep 15;8(2):144.
Bolajoko EB, Akinosun OM, Khine AA. Hyperglycemia-induced oxidative stress in the development of diabetic foot ulcers. In: Diabetes. Elsevier; 2020. p. 35–48.
Oladeji OS, Odelade KA, Oloke JK. Phytochemical screening and antimicrobial investigation of Moringa oleifera leaf extracts. African Journal of Science, Technology, Innovation and Development. 2020;12(1):79–84.
Dewi M, Suryono S, Wulandari P. Aktivitas Renoprotektif Daun Kelor (Moringa oleifera Lamk) pada Tikus Model Diabetes Mellitus Tipe 2. Jurnal Pharmascience. 2022;9(2):201–12.
Satriyani DPP. Review artikel: Aktivitas antioksidan ekstrak daun kelor (Moringa oleifera Lam.). Jurnal Farmasi Malahayati. 2021;4(1):31–43.
Kusuma IY, Pujiarti Y, Samodra G. Potensi Daun Kelor (Moringa Oleifera) Sebagai Agen Anti-Hipergikemia : Studi Literatur Review. JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X. 2020 Jan 31;12(1):94–9.
Shidiq M. Efektivitas Tepung Daun Kelor (Moringa Oleifera) Terhadap Kadar Glukosa Darah Tikus Jantan Galur Wistar Yang Diinduksi Aloksan [Skripsi]. [Jakarta]: Universitas Pembangunan Nasional Veteran ; 2019.
Hidayati EN, Kinanti CD, Masrul MZ. Skrining Fitokimia dan Penentuan Kadar Flavonoid Total Ekstrak Etanol Daun Kelor (Moringa oleifera) Menggunakan Metode Spektrofotometer UV-Vis. JIKES: Jurnal Ilmu Kesehatan. 2023;2(1):14–21.
Sahreni S, Purwati K, Pratama D. Pengaruh Esktrak Daun Krokot (Portulaca Oleracea) Terhadap Kadar Gula Darah Pada Tikus Yang Diinduksi Aloksan. JURNAL RISET RUMPUN ILMU KEDOKTERAN. 2022;1(2):137–47.
Bachmid N. Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Patikan Emas (Euphorbia prunifolia Jacq.) pada Tikus Wistar yang Hiperkolesterolemia. Jurnal MIPA. 2015 Feb 11;4(1):29.
Perkumpulan Endokrinologi Indonesia. Pedoman Pengelolaan dan Pencegahan Diabetes Mellitus Tipe 2 di Indonesia 2021. Jakarta: PB PERKENI; 2021. 6–12 p.
Hakim RF, Idroes R, Hanafiah OA, Ginting B, Fakhrurrazi F. Potential Effect of Red Algae Content on Fibroblasts and Collagen Type 3 in Oral Mucosa Wound Healing Diabetes-Induced Rattus Norvegicus. Tropical Journal of Natural Product Research. 2023;7(8).
Priyanto Y, Christijanti W, Lisdiana L, Marianti A. Aktivitas Antioksidan Daun Kelor (Moringa oleifera) pada Tikus Diabetik Induksi Aloksan. Life Science. 2023;12(1):97–106.
Owens III FS, Dada O, Cyrus JW, Adedoyin OO, Adunlin G. The effects of Moringa oleifera on blood glucose levels: a scoping review of the literature. Complement Ther Med. 2020;50:102362.
Hu S, Wang L, Togo J, Yang D, Xu Y, Wu Y, et al. The carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of mice. Mol Metab. 2020;32:27–43.
