THE IMPACT OF SEIZURES ON COGNITIVE ABILITIES OF PATIENTS DIAGNOSED WITH NEUROCYSTICERCOSIS: A SYSTEMATIC REVIEW
Main Article Content
Neurocysticercosis is one of the most encountered infectious diseases caused by parasites. This condition is caused by an infection of the larvae (cysticercus) of the tapeworm Taenia Solium in the central nervous system. One of the many clinical manifestations of this condition is recurrent seizures that can eventually lead to damage to brain tissue and its functions. This literature review aims to discuss the effect of seizures on the cognitive function of patients diagnosed with neurocysticercosis. The method used in this study is a systematic review with search engines (PubMed and the Cochrane Library) using the keywords “neurocysticercosis” and “seizure” and “cognitive”. Inclusion criteria for this literature review include articles and journals published in the last 10 years with full-text access. We found 6 articles comparing the cognitive abilities of neurocysticercosis-diagnosed patients with healthy control. This literature review concluded that neurocysticercosis patients tend to have lower cognitive function in certain aspects compared to healthy controls.
Keywords:
Neurocysticercosis
kejang
kemampuan kognitif
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Varghese V, Chandra SR, Christopher R, Rajeswaran J, Prasad C, Subasree R, et al. Cognitive Dysfunction and its Determinants in Patients with Neurocysticercosis. Indian J Psychol Med. 2016 Mar 1;38(2):142–6.
Wiwanitkit V. Dementia and neurocysticercosis. Acta Neurol Taiwan. 2014;23(1):1–3.
Bustos J, Gonzales I, Saavedra H, Handali S, Garcia HH. Neurocysticercosis. A frequent cause of seizures, epilepsy, and other neurological morbidity in most of the world. J Neurol Sci. 2021 Aug;427:117527.
Santhosh AP, Kumar Goyal M, Modi M, Kharbanda PS, Ahuja CK, Tandyala N, et al. Carbamazepine versus levetiracetam in epilepsy due to neurocysticercosis. Acta Neurol Scand. 2021 Mar 22;143(3):242–7.
Frackowiak M, Sharma M, Singh T, Mathew A, Michael BD. Antiepileptic drugs for seizure control in people with neurocysticercosis. Cochrane Database of Systematic Reviews. 2019 Oct 14;
Burneo JG, Cavazos JE. Neurocysticercosis and Epilepsy. Epilepsy Curr. 2014 Jan 1;14(2_suppl):23–8.
Winkler AS, Willingham AL, Sikasunge CS, Schmutzhard E. Epilepsy and neurocysticercosis in sub-Saharan Africa. Wien Klin Wochenschr. 2009 Oct 1;121(S3):3–12.
Garcia HH, Gonzalez AE, Gilman RH. Taenia solium cysticercosis and its impact in neurological disease. Clin Microbiol Rev. 2020;33(3):10–1128.
Carpio A, Fleury A, Romo ML, Abraham R. Neurocysticercosis: the good, the bad, and the missing. Expert Rev Neurother. 2018 Apr 3;18(4):289–301.
Ciampi de Andrade D, Rodrigues CL, Abraham R, Castro LHM, Livramento JA, Machado LR, et al. Cognitive impairment and dementia in neurocysticercosis. Neurology. 2010 Apr 20;74(16):1288–95.
Singhi P, Saini AG. Pediatric Neurocysticercosis. The Indian Journal of Pediatrics. 2019 Jan 20;86(1):76–82.
Garcia HH, Gonzalez AE, Gilman RH. Taenia solium Cysticercosis and Its Impact in Neurological Disease. Clin Microbiol Rev. 2020 Jun 17;33(3).
de Oliveira RS, Viana DC, Colli BO, Rajshekhar V, Salomão JFM. Pediatric neurocysticercosis. Child’s Nervous System. 2018 Oct 9;34(10):1957–65.
Garcia HH. Neurocysticercosis. Neurol Clin. 2018 Nov;36(4):851–64.
Gripper LB, Welburn SC. Neurocysticercosis infection and disease–A review. Acta Trop. 2017 Feb;166:218–24.
Singhi P, Suthar R. Neurocysticercosis. The Indian Journal of Pediatrics. 2015 Feb 10;82(2):166–71.
Garcia HH, Nash TE, Del Brutto OH. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol. 2014 Dec;13(12):1202–15.
Gupta MM, Chaudhary N, Pathak S, Agrawal N, Yadav J, Shrestha S, et al. Neurocysticercosis in Children with Seizures: A Cross-Sectional Study. Int J Pediatr. 2018;2018:1–6.
Rajshekhar V. Evolution of concepts in the management of cysticercosis of the brain: Then (1970) and now (2018). Neurol India. 2018;66(4):919.
Debacq G, Moyano LM, Garcia HH, Boumediene F, Marin B, Ngoungou EB, et al. Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. PLoS Negl Trop Dis. 2017 Mar 7;11(3):e0005153.
Singhi P, Malhi P, Suthar R, Deo B, Khandelwal NK. Long-term Cognitive Outcome of Children With Parenchymal Neurocysticercosis: A Prospective Observation Study. J Child Neurol. 2018 Jun 24;33(7):468–73.
Prasad R, Shambhavi, Mishra OP, Upadhyay SK, Singh TB, Singh UK. Cognitive and Behaviour Dysfunction of Children with Neurocysticercosis: A Cross-Sectional Study. J Trop Pediatr. 2014 Oct 1;60(5):358–62.
Verma A, Chopra B, Shankar Kaushik J, Gathwala G. Cognitive and behavioral profile of treatment-naïve children aged 6–14 years with neurocysticercosis from North India. Ann Indian Acad Neurol. 2018;21(4):300.
Del Brutto OH, Mera RM, Zambrano M, Costa AF, Román GC. The Association between Calcified Neurocysticercosis and Cognitive Performance: A Case–Control Study Nested to a Population-Based Cohort. Am J Trop Med Hyg. 2019 Feb 6;100(2):323–6.
Nau AL, Mwape KE, Wiefek J, Schmidt K, Abatih E, Dorny P, et al. Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia. Epilepsy & Behavior. 2018 Mar;80:354–9.
Johnson N, Saini AG, Malhi P, Khandelwal N, Singhi P. Comparison of Long-Term Outcomes Between 7 Days and 28 Days Albendazole Monotherapy in the Treatment of Single-Lesion Neurocysticercosis in Children. J Child Neurol. 2022 Jan 12;37(1):28–34.
Falco-Walter JJ, Scheffer IE, Fisher RS. The new definition and classification of seizures and epilepsy. Epilepsy Res. 2018 Jan;139:73–9.
Venkat B, Aggarwal N, Makhaik S, Sood R. A comprehensive review of imaging findings in human cysticercosis. Jpn J Radiol. 2016 Apr 23;34(4):241–57.
Del Brutto OH, Nash TE, White AC, Rajshekhar V, Wilkins PP, Singh G, et al. Revised diagnostic criteria for neurocysticercosis. J Neurol Sci. 2017 Jan;372:202–10.
Del Brutto OH. Human Neurocysticercosis: An Overview. Pathogens. 2022 Oct 20;11(10):1212.
Ratcliffe C, Adan G, Marson A, Solomon T, Saini J, Sinha S, et al. Neurocysticercosis-related seizures: Imaging biomarkers. Seizure: European Journal of Epilepsy. 2023 May;108:13–23.
Singhi P, GAHLOT A. Pediatric neurocysticercosis: current challenges and future prospects. Pediatric Health Med Ther. 2016 Mar;5.
Nau AL, Mwape KE, Wiefek J, Schmidt K, Abatih E, Dorny P, et al. Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia. Epilepsy & Behavior. 2018 Mar;80:354–9.
Johnson N, Saini AG, Malhi P, Khandelwal N, Singhi P. Comparison of Long-Term Outcomes Between 7 Days and 28 Days Albendazole Monotherapy in the Treatment of Single-Lesion Neurocysticercosis in Children. J Child Neurol. 2022 Jan 12;37(1):28–34.
Varghese V, Chandra SR, Christopher R, Rajeswaran J, Prasad C, Subasree R, et al. Cognitive Dysfunction and its Determinants in Patients with Neurocysticercosis. Indian J Psychol Med. 2016 Mar 1;38(2):142–6.
Wiwanitkit V. Dementia and neurocysticercosis. Acta Neurol Taiwan. 2014;23(1):1–3.
Bustos J, Gonzales I, Saavedra H, Handali S, Garcia HH. Neurocysticercosis. A frequent cause of seizures, epilepsy, and other neurological morbidity in most of the world. J Neurol Sci. 2021 Aug;427:117527.
Santhosh AP, Kumar Goyal M, Modi M, Kharbanda PS, Ahuja CK, Tandyala N, et al. Carbamazepine versus levetiracetam in epilepsy due to neurocysticercosis. Acta Neurol Scand. 2021 Mar 22;143(3):242–7.
Frackowiak M, Sharma M, Singh T, Mathew A, Michael BD. Antiepileptic drugs for seizure control in people with neurocysticercosis. Cochrane Database of Systematic Reviews. 2019 Oct 14;
Burneo JG, Cavazos JE. Neurocysticercosis and Epilepsy. Epilepsy Curr. 2014 Jan 1;14(2_suppl):23–8.
Winkler AS, Willingham AL, Sikasunge CS, Schmutzhard E. Epilepsy and neurocysticercosis in sub-Saharan Africa. Wien Klin Wochenschr. 2009 Oct 1;121(S3):3–12.
Garcia HH, Gonzalez AE, Gilman RH. Taenia solium cysticercosis and its impact in neurological disease. Clin Microbiol Rev. 2020;33(3):10–1128.
Carpio A, Fleury A, Romo ML, Abraham R. Neurocysticercosis: the good, the bad, and the missing. Expert Rev Neurother. 2018 Apr 3;18(4):289–301.
Ciampi de Andrade D, Rodrigues CL, Abraham R, Castro LHM, Livramento JA, Machado LR, et al. Cognitive impairment and dementia in neurocysticercosis. Neurology. 2010 Apr 20;74(16):1288–95.
