MESENCHYMAL STEM CELLS (MSCS) AS A THERAPY FOR CHRONIC WOUND HEALING IN DIABETIC FOOT ULCERS: A REVIEW ARTICLE
Main Article Content
Diabetic foot ulcer is a chronic and frequent complication in diabetic patients. Foot ulcers occur in 15-25% of people with diabetes, and most of them require amputation. Conventional treatments for DFU have not been effective enough to reduce the amputation rates. Thus, an effective method to accelerate the healing of diabetic foot ulcers is required. Recently, stem cells have emerged as a promising adjuvant therapy. One of the numerous types of stem cells used in chronic wound healing therapy is Mesenchymal Stem Cells (MSCs). MSCs may be associated with shorter wound healing time, rapid tissue regeneration, and reduced risk of lower limb amputation through all mechanisms. This article summarizes and critically reviews the published literature on the use of MSCs to enhance chronic wound healing in DFUs.
Keywords:
MSC's
penyembuhan luka
ulkus kaki diabetik
Mesenchymal Stem Cells
diabetic foot ulcer
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El Hage R, Knippschild U, Arnold T, Hinterseher I. Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer. Biomedicines. 2022;10(7):1–22.
Shu X, Shu S, Tang S, Yang L, Liu D, Li K, et al. The efficiency of stem cell-based therapy in the treatment of diabetic foot ulcers: A meta-analysis. Endocr J. 2018;65(4):403–13.
Zhao L, Guo Z, Chen K, Yang W, Wan X, Zeng P, et al. Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing. Stem Cells Int. 2020;2020.
Chen G, Yue A, Ruan Z, Yin Y, Wang R, Ren Y, et al. Comparison of biological characteristics of mesenchymal stem cells derived from maternal-origin placenta and Wharton's jelly. Stem Cell Res Ther [Internet]. 2015;6(1):1–7. Available from: http://dx.doi.org/10.1186/s13287-015-0219-6
AI A, S. AN, PH B, M. AS, C. B, E. H, et al. Human Wharton's jelly mesenchymal stem cells promote skin wound healing through paracrine signaling. Stem Cell Res Ther. 2014;5(1):1–13.
Nalisa DL, Moneruzzaman M, Changwe GJ, Mobet Y, Li LP, Ma YJ, et al. Stem Cell Therapy for Diabetic Foot Ulcers: Theory and Practice. J Diabetes Res. 2022;2022.
Lee DE, Ayoub N, Agrawal DK. Mesenchymal stem cells and cutaneous wound healing: Novel methods to increase cell delivery and therapeutic efficacy. Stem Cell Res Ther [Internet]. 2016;7(1):1–8. Available from: http://dx.doi.org/10.1186/s13287-016-0303-6
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Jiayi Yang. Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration. Int Nanomedicine [Internet]. 2020;11(15):5911–26. Available from: https://pubmed.ncbi.nlm.nih.gov/32848396/
