Candida albicans is mostly found in oral cavity as an opportunistic microbiota in some oral mucous diseases. The papaya peel extract is a rich source of antifungal compounds. The aimed of this study was to determine antifungal effect of carica papaya peel extract againts Candida albicans. This study was experimental laboratory with post-test only control group design. The macerated ethanol extract of papaya peel were divided into six groups based on its concentrations. It consisted of 2.5%, 5%, 10%, 20% concentration of papaya peel extract, nystatin as positive control, and distilled water as negative control. All concentration of papaya peel extracts were effective against the growth of C. albicans. The minimum inhibitory concentration was 2.5%. Conclusion of this research shows that the extract of papaya peel var Califonia has antifungal effect against C. albicans.